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Greetings from Toby's Foundation,

Toby's Foundation's grant for Dr. Karen Munana at NCSU for the project “The Pharmacokinetics of Levetiracetam in Epileptic Dogs When Used Concurrently with Other Antiepileptics” has concluded.


"This study was undertaken to determine whether the metabolism of the anti-seizure drug levetiracetam (LEV) varies depending on whether it is given in combination with phenobarbital and/or potassium bromide to dogs with epilepsy. Dogs previously diagnosed with epilepsy that were being treated with LEV in addition to phenobarbital, potassium bromide or both were studied. Blood samples were collected at 5 time points within a 6-hour period for measurement of LEV levels. The study demonstrated that there is considerable variability in blood levels of LEV among dogs that are receiving LEV as a treatment for epilepsy. The group of dogs being administered LEV and bromide in combination tended to have the highest blood LEV levels, followed by the group receiving LEV and phenobarbital in combination, while the group receiving LEV, phenobarbital and bromide in combination tended to have the lowest blood LEV levels. This suggests that the administration of phenobarbital, with or without bromide, might affect the metabolism of LEV when the drugs are used together to treat epilepsy in dogs. Based on the study results, it is recommended that LEV blood levels be measured in dogs that are receiving LEV in combination with other drugs, particularly if adequate seizure control is not achieved. Additional studies are required to determine a recommended target LEV range in dogs that is associated with seizure control."


This study can advance more effective treatments for dogs suffering from canine epilepsy. There is more detailed information that will become available after the study is published.

Julie Osborne at North Carolina State University is seeking more respondents for their online study “Impacts of Epilepsy in Companion Animal Patients.”

Julie writes:


"Hi all:


Thank you for your support in helping us to get the word out regarding the online study, "Impacts of Epilepsy in Companion Animal Patients." To date, we have more than a 100 respondents, and would like to add a few more.


Please feel free to forward the above link to clients or include on list-serves for owners with pets facing epilepsy.  We appreciate your continued support of this project.  Do not hesitate to contact me with any questions whatsoever.


Warm Regards,



Julie Ann Nettifee Osborne, RVT, BS, VTS (Neurology)

North Carolina State University

College of Veterinary Medicine

Department of Clinical Sciences

1060 William Moore Drive

Raleigh, NC  27607

919-513-6812 Phone

919-513-6830 FAX

REMINDER: Purple Day is March 26

Please wear purple on that day to join with others from around the globe to raise epilepsy awareness. Visit for more information. Epilepsy affects both canines and humans…“Same Disease Different Species!”  

Please visit our website to view current photos.


Charitable Giving

Your gifts help us to support the research to find the genes responsible for canine epilepsy and develop a screening test.

Please make Toby's Foundation part of your charitable giving. Toby's Foundation, Inc. is a non-profit 501(c)(3) organization. Our Federal Tax Identification number is 74-3135217. Your gift is tax deductible to the fullest extent of the law and helps us in our efforts to stop canine epilepsy. Please check with your employer about a Matching Gifts program.

If you would like to make a memorial or honorary gift to support canine epilepsy research, an acknowledgement card can be sent to whomever you specify.

We accept donations online (see link below) or you may mail your check to:

Toby's Foundation
P.O. Box 7321
Laguna Niguel , CA 92607

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AussiE-Update Volume VI, No. 42
February 27, 2012

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P.O. Box 7321
Laguna Niguel, California 92607

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